Overview Caring for cardiac patients can present a host of dilemmas for the general hospital psychiatrist. Patients with psychiatric conditions may exhibit cardiac symptoms, psychotropic agents can result in electrocardiographic abnormalities, and psychiatric manifestations may result from cardiac conditions. Because the overlap between psychiatry and cardiology is so great, knowledge of ways to manage specific problems can be of tremendous benefit. For instance, knowing how to deal with chest pain in the face of a psychiatric syndrome, an electrocardiographic complication from a psychotropic agent, or delirium due to cerebral hypoperfusion, can facilitate comprehensive and compassionate care. This chapter focuses on three main psychiatric syndromes related to the cardiac patient: anxiety, depression, and delirium. For each of these syndromes, we will consider epidemiology, clinical manifestations, differential diagnosis, psychopharmacologic approaches, and practical management strateg...